A further 61 cases of swine flu have been confirmed in England, bringing the UK total to 1,226, health officials have said.
There have now been 752 cases confirmed in England, 463 in Scotland, eight in Northern Ireland and three in Wales, said the Health Protection Agency.
Of the new cases, 39 appeared in the West Midlands, where 354 people have now been affected by the virus.
Another 486 possible UK cases are being investigated.
Of the new cases, there were nine in London, seven in Yorkshire and Humberside, three in the South East, two in the East of England and one in the South West.
Saturday saw the biggest one-day rise in the number of confirmed infections, with 172 patients in England and Scotland confirmed with the H1N1 virus.
On Friday, Health Secretary Andy Burnham encouraged people not to panic after the World Health Organisation announced the world is now in the grip of a flu pandemic, the first in more than 40 years.
He said the UK was well-prepared and the WHO's announcement did not affect the assessment of how the virus was behaving in the UK.
The last flu pandemic in 1968 killed about a million people.
Around 30,000 cases of swine flu have so far been detected in more than 70 countries and at least 145 people have died worldwide.
